Job Description
Job Details
Level Experienced
Job Location National Institutes of Health (NIH) - Gaithersburg Campus - Gaithersburg, MD
Position Type Full Time
Education Level Bachelors Degree
Travel Percentage None
Job Shift Day
Job Category Public Health
Description Position Objective: Provide services as a Biologist in support of the overall functions of the Vaccine Production Program (VPP), Vaccine Research Center (VRC) within the National Institute of Allergy and Infectious Diseases (NIAID).
Duties and Responsibilities: - Develop downstream (purification) processes for recombinant proteins, virus vaccines, virus-like particles (VLP) and nucleic acids, that may be used as clinical candidates.
- Work collaboratively within the purification group to design, develop and optimize chromatography and filtration step (Normal Flow Filtration and Tangential Flow Filtration) unit operations to support process development of clinical trial vaccine candidates and mAb products.
- Purify research-phase recombinant proteins, virus vaccines, virus-like particles and/or nucleic acids in support of other groups or external collaborators.
- Work to prepare necessary materials (buffers, packed columns, etc.) in support of downstream process activities.
- Support technology transfer of processes to Lab's Pilot Plant for manufacture of clinical product through document generation and on-site support.
- Write and review technical protocols, reports and technology transferdocuments.
- Analyze and compile data, present at various group/departmentmeetings.
- Work collaboratively to design, run and analyze high throughput screens using TECAN automated bioprocessing system.
- PerformIn vitroTranscription (IVT) and mRNA purification at multiplescales.
- Design and execute day to day development operations with minimalsupervision.
Qualifications Basic Qualifications: - Bachelor's degree in Bioengineering, Chemical Engineering, Biochemistry, or a relateddiscipline.
- Minimum of two to five (2-5) years of experience in recombinant protein, pDNA, and mRNA purification development for GMP clinical-phase products.
- Experience with In vitro Transcription (IVT) and mRNApurification.
- Experience using high-throughput bioprocessing systems such asTECAN.
- Familiarity with computer software including word processing and dataevaluation.
Minimum Qualifications: - Demonstrated knowledge of maintaining accurate and detailedrecords.
- Must be a team player who can effectively work with members from cross-functionaldepartments.
- Strong oral and written communicationskills.
- Ability to communicate effectively, orally and in writing, with non-technical and technical staff.
- Detail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects
*This is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.
To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
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Job Tags
Full time, Shift work,